منابع مشابه
Genomic organization and evolution of double minutes/homogeneously staining regions with MYC amplification in human cancer
The mechanism for generating double minutes chromosomes (dmin) and homogeneously staining regions (hsr) in cancer is still poorly understood. Through an integrated approach combining next-generation sequencing, single nucleotide polymorphism array, fluorescent in situ hybridization and polymerase chain reaction-based techniques, we inferred the fine structure of MYC-containing dmin/hsr amplicon...
متن کاملDouble minutes, cytogenetic equivalents of gene amplification, in human neoplasia - a review.
Double minutes are tiny spherical chromatin bodies of a few mega-base pairs of size which are found occasionally in hematopoietic neoplasia and more or less often in human solid tumors. They have been associated with worse prognosis and poor outcome of the malignancies where present. With the beginning era of molecular cytogenetics they could be defined as cytogenetic equivalents of amplified D...
متن کاملAmplification units containing human N-myc and c-myc genes.
The amplification units in human tumors containing amplified myc genes were examined. The amplification unit in all cases consisted of a large genomic region coamplified with the coding region of the myc genes themselves. In eight independent neuroblastomas containing N-myc amplifications, the amplification unit was estimated to be 290 to 430 kilobases. This amplification unit was highly conser...
متن کاملMYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene.
Double minutes (dmin)-circular, extra-chromosomal amplifications of specific acentric DNA fragments-are relatively frequent in malignant disorders, particularly in solid tumors. In acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), dmin are observed in approximately 1% of the cases. Most of them consist of an amplified segment from chromosome band 8q24, always including the MYC g...
متن کاملassociation between amplification and expression of c-myc gene and clinicopathological characteristics of stomach cancer
background the incidence rate of gastric cancer in western countries has shown a remarkable decline in the recent years while it is still the most common cancer among males in iran. the proto-oncogene myc, located at 8q24.1, regulates almost 15% of human genes and is activated in 20% of all tumors. the amplification of myc and overexpression of its protein product are observed in 15 - 30% of ga...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2014
ISSN: 1943-7722,0002-9173
DOI: 10.1309/ajcpwubgt7c0lhin